Zn2+   Click here for help

GtoPdb Ligand ID: 566

Synonyms: zinc | zinc ion
Compound class: Inorganic
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Natural/Endogenous Targets
Target
5-HT3A
β2-adrenoceptor
GABAA receptor α1 subunit
GABAA receptor α2 subunit
GABAA receptor α3 subunit
GABAA receptor α4 subunit
GABAA receptor α5 subunit
GABAA receptor α6 subunit
Glycine Receptor (All subtypes)
glycine receptor α1 subunit
glycine receptor α2 subunit
glycine receptor α3 subunit
glycine receptor β subunit
GPR39
ZAC
Cofactor in Enzyme Reactions
Enzyme Reference
Endothelial NOS
NG,NG-Dimethylarginine dimethylaminohydrolase 1
Inducible NOS
Neuronal NOS
3-Mercaptopyruvate sulfurtransferase
geranylgeranyl diphosphate synthase 22
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
Solute carrier family 41 member 1 7
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
β2-adrenoceptor Ligand is endogenous in the given species Hs Allosteric modulator Positive 5.3 pKi - 19-20
pKi 5.3 [19-20]
β2-adrenoceptor Ligand is endogenous in the given species Hs Allosteric modulator Negative 3.3 pKi - 19-20
pKi 3.3 [19-20]
GPR83 Mm Agonist Full agonist 5.0 pEC50 - 17
pEC50 5.0 (EC50 1.02x10-5 M) [17]
GPR39 Ligand is endogenous in the given species Hs Agonist Agonist - - - 8
[8]
Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Kir2.3 Hs Channel blocker Antagonist - - 5x10-5 - 3x10-4 4
Conc range: 5x10-5 - 3x10-4 M [4]
Voltage: -100.0 – 0.0 mV
5-HT3A Ligand is endogenous in the given species Mm Allosteric modulator Biphasic - - 1x10-6 - 3x10-4 6,10
Conc range: 1x10-6 - 3x10-4 M Positive (1-10μM): increased potency of 5-HT, decreased desensitization rate, reduced effect in the presence of Mg2+ or Ca2+. Negative (30-300μM). [6,10]
Glycine Receptor (All subtypes) Ligand is endogenous in the given species Hs Allosteric modulator Inhibition - - 1x10-5 13-14,16
Conc range: 1x10-5 M [13-14,16]
Glycine Receptor (All subtypes) Ligand is endogenous in the given species Hs Allosteric modulator Potentiation - - 2x10-8 - 1x10-5 2,13-14,16
Conc range: 2x10-8 - 1x10-5 M [2,13-14,16]
Glycine Receptor (All subtypes) Ligand is endogenous in the given species N/A Subunit-specific Inhibition - - < 1x10-6 15
Conc range: < 1x10-6 M α1, α2 >> α1β, α2β [15]
Glycine Receptor (All subtypes) Ligand is endogenous in the given species N/A Subunit-specific Potentiation - - < 1x10-8 16
Conc range: < 1x10-8 M α1, α1β > α2, α2β [16]
glycine receptor α1 subunit Ligand is endogenous in the given species Hs Allosteric modulator Potentiation 7.4 pEC50 -
pEC50 7.4 (EC50 3.7x10-8 M) endogenous; not affected by β subunit co-expression
glycine receptor α2 subunit Ligand is endogenous in the given species Hs Allosteric modulator Potentiation 6.3 pEC50 -
pEC50 6.3 (EC50 5.4x10-7 M) endogenous; not affected by β subunit co-expression
ZAC Ligand is endogenous in the given species Hs Agonist Agonist 3.3 – 3.7 pEC50 - 5,21
pEC50 3.3 – 3.7 [5,21]
TRPA1 Mm Activator Activation 2.3 pEC50 - 1,9
pEC50 2.3 Zinc has similar activity at the human TRPA1 [1,9]
Description: Calcium imaging
Conditions: HEK293 cells expressing human TRPA1 and mouse dorsal root ganglia neurons loaded with Fura-2
ASIC1 Hs Channel blocker - ~8.2 pIC50 - 3
pIC50 ~8.2 (IC50 ~7x10-9 M) ASIC1a [3]
TRPM1 Ligand is endogenous in the given species Hs Channel blocker - 6.0 pIC50 -
pIC50 6.0 (IC50 1x10-6 M)
TRPM2 Ligand is endogenous in the given species Hs Channel blocker - 6.0 pIC50 -
pIC50 6.0 (IC50 1x10-6 M)
Hv1 Hs Channel blocker - ~5.7 – 6.3 pIC50 -
pIC50 ~5.7 – 6.3 (IC50 ~2x10-6 – 5x10-7 M)
glycine receptor α1 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition 4.8 pIC50 -
pIC50 4.8 (IC50 1.5x10-5 M) endogenous
glycine receptor β subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition 3.7 – 4.9 pIC50 -
pIC50 4.9 (IC50 1.3x10-5 M) endogenous; when co-expressed with the α1 subunit
pIC50 3.7 (IC50 1.8x10-4 M) endogenous; when co-expressed with the α2 subunit
ClC-4 Hs Channel blocker - 4.3 pIC50 - 18
pIC50 4.3 (IC50 5x10-5 M) [18]
Maxi Cl- Hs Channel blocker (extracellular Zn2+) - 4.3 pIC50 - 18
pIC50 4.3 (IC50 5x10-5 M) [18]
ASIC3 Hs Channel blocker - 4.2 pIC50 - 11
pIC50 4.2 (IC50 6.1x10-5 M) [11]
glycine receptor α3 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition 3.8 pIC50 -
pIC50 3.8 (IC50 1.5x10-4 M) endogenous
glycine receptor α2 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition 3.4 pIC50 -
pIC50 3.4 (IC50 3.6x10-4 M) endogenous
GABAA receptor α1 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition - - -
GABAA receptor α2 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition - - -
GABAA receptor α3 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition - - -
GABAA receptor α4 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition - - -
GABAA receptor α5 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition - - -
GABAA receptor α6 subunit Ligand is endogenous in the given species Hs Allosteric modulator Inhibition - - -
Kv12.1 Mm Gating inhibitor - - - - 23
[23]
Description: 1 mM Zn2+ slows activation 10-fold and shifts V0.5 for activation by ~+47 mV
Conditions: Heterologous expression in Xenopus oocytes
ClC-1 Hs Channel blocker - - - -
ClC-2 Hs Channel blocker - - - -
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields