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Synonyms: methyl hydrogen fumarate
Compound class: Synthetic organic
Comment: Monomethyl fumarate (MMF) is the active metabolite of the approved drug dimethyl fumarate (DMF).
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: monomethylfumarate
1. Tang H, Lu JY, Zheng X, Yang Y, Reagan JD. (2008)
The psoriasis drug monomethylfumarate is a potent nicotinic acid receptor agonist.
Biochem. Biophys. Res. Commun., 375 (4): 562-5. [PMID:18722346]
2. van Veldhoven JP, Blad CC, Artsen CM, Klopman C, Wolfram DR, Abdelkadir MJ, Lane JR, Brussee J, Ijzerman AP. (2011)
Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A).
Bioorg. Med. Chem. Lett., 21 (9): 2736-9. [PMID:21167710]