Synonyms: Cozaar® | DuP 753 | MK-954
losartan is an approved drug (FDA (1995))
Compound class:
Synthetic organic
Comment: Losartan is an angiotensin II (AT2) receptor antagonist drug.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖![]() View more information in the IUPHAR Pharmacology Education Project: losartan |
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References |
1. Burns CM, Wortmann RL. (2011)
Gout therapeutics: new drugs for an old disease. Lancet, 377 (9760): 165-77. [PMID:20719377] |
2. de Gasparo M, Whitebread S, Bottari SP, Levens NR. (1994)
Heterogeneity of angiotensin receptor subtypes. In Medicinal Chemistry of the Renin-Angiotensin System. Edited by Timmermanns PBMWM, Wexler RR (Elsevier) 269-294. [ISBN:0444820531] |
3. Hamada T, Ichida K, Hosoyamada M, Mizuta E, Yanagihara K, Sonoyama K, Sugihara S, Igawa O, Hosoya T, Ohtahara A et al.. (2008)
Uricosuric action of losartan via the inhibition of urate transporter 1 (URAT 1) in hypertensive patients. Am J Hypertens, 21 (10): 1157-62. [PMID:18670416] |
4. Timmermans PB, Wong PC, Chiu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JA, Smith RD. (1993)
Angiotensin II receptors and angiotensin II receptor antagonists. Pharmacol Rev, 45 (2): 205-51. [PMID:8372104] |