losartan

Ligand id: 590

Name: losartan

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 92.51
Molecular weight 422.16
XLogP 6.14
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1995))
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
[2-butyl-5-chloro-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol
International Nonproprietary Names
INN number INN
6913 losartan
Synonyms
Cozaar® | DuP 753 | MK-954
Comments
Losartan is an angiotensin II (AT2) receptor antagonist drug.
Database Links
CAS Registry No. 114798-26-4 (source: DrugBank)
ChEBI CHEBI:6541
ChEMBL Ligand CHEMBL191
DrugBank Ligand DB00678
GtoPdb PubChem SID 135650532
PubChem CID 3961
RCSB PDB Ligand LSN
Search Google for chemical match using the InChIKey PSIFNNKUMBGKDQ-UHFFFAOYSA-N
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Search UniChem for chemical match using the InChIKey PSIFNNKUMBGKDQ-UHFFFAOYSA-N
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Wikipedia Losartan