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Synonyms: ZM-39923 | ZM39923
Compound class: Synthetic organic
Comment: This is compound 7 in , and is also known as ZM39923. It was originally identified as an ATP-binding site inhibitor of JAK3 , but has additionally been reported to inhibit transglutaminase 2 (TGM2) with nanomolar potency in vitro .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]
2. Brown GR, Bamford AM, Bowyer J, James DS, Rankine N, Tang E, Torr V, Culbert EJ. (2000)
Naphthyl ketones: a new class of Janus kinase 3 inhibitors.
Bioorg. Med. Chem. Lett., 10 (6): 575-9. [PMID:10741557]
3. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013)
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Biochem. J., 451 (2): 313-28. [PMID:23398362]
4. Lai TS, Liu Y, Tucker T, Daniel KR, Sane DC, Toone E, Burke JR, Strittmatter WJ, Greenberg CS. (2008)
Identification of chemical inhibitors to human tissue transglutaminase by screening existing drug libraries.
Chem. Biol., 15 (9): 969-78. [PMID:18804034]
5. Luo C, Laaja P. (2004)
Inhibitors of JAKs/STATs and the kinases: a possible new cluster of drugs.
Drug Discov. Today, 9 (6): 268-75. [PMID:15003245]