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Synonyms: PEP-005 | Picato®
ingenol mebutate is an approved drug (FDA & EMA (2012))
Compound class: Natural product or derivative
Comment: Ingenol mebutate is extracted from the plant Euphorbia peplus.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Challacombe JM, Suhrbier A, Parsons PG, Jones B, Hampson P, Kavanagh D, Rainger GE, Morris M, Lord JM, Le TT et al.. (2006)
Neutrophils are a key component of the antitumor efficacy of topical chemotherapy with ingenol-3-angelate.
J. Immunol., 177 (11): 8123-32. [PMID:17114487]
2. Kedei N, Lundberg DJ, Toth A, Welburn P, Garfield SH, Blumberg PM. (2004)
Characterization of the interaction of ingenol 3-angelate with protein kinase C.
Cancer Res., 64 (9): 3243-55. [PMID:15126366]
3. Lebwohl M, Swanson N, Anderson LL, Melgaard A, Xu Z, Berman B. (2012)
Ingenol mebutate gel for actinic keratosis.
N. Engl. J. Med., 366 (11): 1010-9. [PMID:22417254]
4. Siller G, Gebauer K, Welburn P, Katsamas J, Ogbourne SM. (2009)
PEP005 (ingenol mebutate) gel, a novel agent for the treatment of actinic keratosis: results of a randomized, double-blind, vehicle-controlled, multicentre, phase IIa study.
Australas. J. Dermatol., 50 (1): 16-22. [PMID:19178487]