ingenol mebutate   Click here for help

GtoPdb Ligand ID: 7443

Synonyms: PEP-005 | Picato®
Approved drug PDB Ligand
ingenol mebutate is an approved drug (FDA & EMA (2012))
Compound class: Natural product
Comment: Ingenol mebutate is extracted from the plant Euphorbia peplus.
Click here for help
2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 4
Topological polar surface area 104.06
Molecular weight 430.24
XLogP 3.21
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help
Canonical SMILES CC=C(C(=O)OC1C(=CC23C1(O)C(O)C(=CC(C3=O)C1C(CC2C)C1(C)C)CO)C)C
Isomeric SMILES C/C=C(\C(=O)O[C@H]1C(=C[C@]23[C@]1(O)[C@H](O)C(=C[C@H](C3=O)[C@H]1[C@@H](C[C@H]2C)C1(C)C)CO)C)/C
InChI InChI=1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1
InChI Key VDJHFHXMUKFKET-WDUFCVPESA-N
Classification Click here for help
Compound class Natural product
Approved drug? Yes (FDA & EMA (2012))
International Nonproprietary Names Click here for help
INN number INN
9006 ingenol mebutate
Synonyms Click here for help
PEP-005 | Picato®
Database Links Click here for help
CAS Registry No. 75567-37-2
ChEBI CHEBI:66913
ChEMBL Ligand CHEMBL1863513
DrugBank Ligand DB05013
DrugCentral Ligand 4226
GtoPdb PubChem SID 178104015
PubChem CID 6918670
RCSB PDB Ligand WUD
Search Google for chemical match using the InChIKey VDJHFHXMUKFKET-WDUFCVPESA-N
Search Google for chemicals with the same backbone VDJHFHXMUKFKET
Search PubMed clinical trials ingenol mebutate
Search PubMed titles ingenol mebutate
Search PubMed titles/abstracts ingenol mebutate
UniChem Compound Search for chemical match using the InChIKey VDJHFHXMUKFKET-WDUFCVPESA-N
UniChem Connectivity Search for chemical match using the InChIKey VDJHFHXMUKFKET-WDUFCVPESA-N
Wikipedia Ingenol mebutate

Product suppliers

View disclaimer

Tocris
PEP 005 (links to external site)
Cat. No. 4054