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Synonyms: JZL 195 | JZL-195
Compound class: Synthetic organic
Comment: JZL195 was first reported as a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL, a.k.a. MAGL) in 2009 . Animal experiments suggest that dual FAAH/MAGL inhibitiors may have improved analgesic effects against neuropathic pain, in comparison to selective FAAH and MAGL inhibitors, or cannabinoid receptor agonists [1-2,4,6].
JZL195 has since been reported to also inhibit acyloxyacyl hydrolase (AOAH) 
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Adamson Barnes NS, Mitchell VA, Kazantzis NP, Vaughan CW. (2016)
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine neuropathic pain model.
Br. J. Pharmacol., 173 (1): 77-87. [PMID:26398331]
2. Anderson WB, Gould MJ, Torres RD, Mitchell VA, Vaughan CW. (2014)
Actions of the dual FAAH/MAGL inhibitor JZL195 in a murine inflammatory pain model.
Neuropharmacology, 81: 224-30. [PMID:24384256]
3. Bachovchin DA, Koblan LW, Wu W, Liu Y, Li Y, Zhao P, Woznica I, Shu Y, Lai JH, Poplawski SE et al.. (2014)
A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity.
Nat. Chem. Biol., 10 (8): 656-63. [PMID:24997602]
4. Ghosh S, Kinsey SG, Liu QS, Hruba L, McMahon LR, Grim TW, Merritt CR, Wise LE, Abdullah RA, Selley DE et al.. (2015)
Full Fatty Acid Amide Hydrolase Inhibition Combined with Partial Monoacylglycerol Lipase Inhibition: Augmented and Sustained Antinociceptive Effects with Reduced Cannabimimetic Side Effects in Mice.
J. Pharmacol. Exp. Ther., 354 (2): 111-20. [PMID:25998048]
5. Long JZ, Nomura DK, Vann RE, Walentiny DM, Booker L, Jin X, Burston JJ, Sim-Selley LJ, Lichtman AH, Wiley JL et al.. (2009)
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo.
Proc. Natl. Acad. Sci. U.S.A., 106 (48): 20270-5. [PMID:19918051]
6. Sakin YS, Dogrul A, Ilkaya F, Seyrek M, Ulas UH, Gulsen M, Bagci S. (2015)
The effect of FAAH, MAGL, and Dual FAAH/MAGL inhibition on inflammatory and colorectal distension-induced visceral pain models in Rodents.
Neurogastroenterol. Motil., 27 (7): 936-44. [PMID:25869205]