GtoPdb Ligand ID: 8606

Synonyms: JZL 195 | JZL-195
Compound class: Synthetic organic
Comment: JZL195 was first reported as a dual inhibitor of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL, a.k.a. MAGL) in 2009 [5]. Animal experiments suggest that dual FAAH/MAGL inhibitiors may have improved analgesic effects against neuropathic pain, in comparison to selective FAAH and MAGL inhibitors, or cannabinoid receptor agonists [1-2,4,6].
JZL195 has since been reported to also inhibit acyloxyacyl hydrolase (AOAH) [3]
2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 8
Topological polar surface area 85.15
Molecular weight 433.16
XLogP 4.32
No. Lipinski's rules broken 0
Canonical SMILES O=C(N1CCN(CC1)Cc1cccc(c1)Oc1ccccc1)Oc1ccc(cc1)[N+](=O)[O-]
Isomeric SMILES O=C(N1CCN(CC1)Cc1cccc(c1)Oc1ccccc1)Oc1ccc(cc1)[N+](=O)[O-]
InChI InChI=1S/C24H23N3O5/c28-24(32-22-11-9-20(10-12-22)27(29)30)26-15-13-25(14-16-26)18-19-5-4-8-23(17-19)31-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2
Selectivity at enzymes
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Fatty acid amide hydrolase Hs Inhibitor Inhibition 8.7 pIC50 - 5
pIC50 8.7 (IC50 2x10-9 M) [5]
Description: in vitro assay
Monoacylglycerol lipase Hs Inhibitor Inhibition 8.4 pIC50 - 5
pIC50 8.4 (IC50 4x10-9 M) [5]
Description: in vitro assay
acyloxyacyl hydrolase Hs Inhibitor Inhibition 7.4 pIC50 - 3
pIC50 7.4 (IC50 4.4x10-8 M) [3]