L-740093

Ligand id: 881

Name: L-740093

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 77.04
Molecular weight 445.25
XLogP 4.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Nilsson I, Monstein HJ, Lindström E, HÃ¥kanson R, Svensson S. (2002)
Pharmacological analysis of CCK(2) receptor ligands using COS-7 and SK-N-MC cells, expressing the human CCK(2) receptor.
Regul. Pept., 103 (1): 29-37. [PMID:11738246]
2. Patel S, Smith AJ, Chapman KL, Fletcher AE, Kemp JA, Marshall GR, Hargreaves RJ, Ryecroft W, Iversen LL, Iversen SD et al.. (1994)
Biological properties of the benzodiazepine amidine derivative L-740,093, a cholecystokinin-B/gastrin receptor antagonist with high affinity in vitro and high potency in vivo.
Mol. Pharmacol., 46 (5): 943-8. [PMID:7969084]