ruxolitinib   Click here for help

GtoPdb Ligand ID: 5688

Synonyms: (R)-ruxolitinib | INC424 | INCB 18424 | INCB018424 | Jakafi® | Jakavi®
Approved drug PDB Ligand Immunopharmacology Ligand
ruxolitinib is an approved drug (FDA (2011), EMA (2012))
Compound class: Synthetic organic
Comment: Ruxolitinib is a Type-1 kinase inhibitor and was first approved by the US FDA in 2011. Ruxolitinib has high potency against Janus kinases 1 and 2 (JAK1, JAK2), as well as against the related family member, tyrosine kinase 2 (TYK2) [3]. Inhibitory activity against JAK3 is only slightly reduced compared to the other three family kinases.
Marketed formulations may contain ruxolitinib phosphate (PubChem CID 25127112).
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 83.18
Molecular weight 306.16
XLogP 2.7
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES N#CCC(n1ncc(c1)c1ncnc2c1cc[nH]2)C1CCCC1
Isomeric SMILES N#CC[C@@H](n1ncc(c1)c1ncnc2c1cc[nH]2)C1CCCC1
InChI InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
InChI Key HFNKQEVNSGCOJV-OAHLLOKOSA-N

Large-scale screening data

DiscoveRx KINOMEscan® screen Click here for help
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 2,7

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value Parameter
Janus kinase 2 JAK2(JH1domain-catalytic) Hs Inhibitor Inhibition 10.4 pKd
tyrosine kinase 2 TYK2(JH1domain-catalytic) Hs Inhibitor Inhibition 9.1 pKd
Janus kinase 3 JAK3(JH1domain-catalytic) Hs Inhibitor Inhibition 8.7 pKd
Janus kinase 1 JAK1(JH1domain-catalytic) Hs Inhibitor Inhibition 8.5 pKd
mitogen-activated protein kinase kinase kinase 2 MAP3K2 Hs Inhibitor Inhibition 7.4 pKd
calcium/calmodulin-dependent protein kinase II alpha subunit CAMK2A Hs Inhibitor Inhibition 7.3 pKd
Rho associated coiled-coil containing protein kinase 2 ROCK2 Hs Inhibitor Inhibition 7.3 pKd
Rho associated coiled-coil containing protein kinase 1 ROCK1 Hs Inhibitor Inhibition 7.2 pKd
doublecortin like kinase 1 DCAMKL1 Hs Inhibitor Inhibition 7.2 pKd
death associated protein kinase 1 DAPK1 Hs Inhibitor Inhibition 7.1 pKd
Displaying the top 10 targets  View all targets in screen »