JNJ-28312141

Ligand id: 5689

Name: JNJ-28312141

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 105.12
Molecular weight 460.26
XLogP 2.82
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value Parameter
ret proto-oncogene RET(V804M) Hs Inhibitor Inhibition 9.1 pKd
ret proto-oncogene RET(V804L) Hs Inhibitor Inhibition 8.9 pKd
fms related tyrosine kinase 3 FLT3(D835Y) Hs Inhibitor Inhibition 8.8 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT(L576P) Hs Inhibitor Inhibition 8.6 pKd
fms related tyrosine kinase 3 FLT3(D835H) Hs Inhibitor Inhibition 8.6 pKd
colony stimulating factor 1 receptor CSF1R Hs Inhibitor Inhibition 8.5 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT Hs Inhibitor Inhibition 8.4 pKd
protein kinase AMP-activated catalytic subunit alpha 2 AMPK-alpha2 Hs Inhibitor Inhibition 8.4 pKd
fms related tyrosine kinase 3 FLT3(ITD) Hs Inhibitor Inhibition 8.4 pKd
AXL receptor tyrosine kinase AXL Hs Inhibitor Inhibition 8.3 pKd
Displaying the top 10 targets  View all targets in screen »