JAK3 inhibitor VI   Click here for help

GtoPdb Ligand ID: 5995

Synonyms: HMS3229G13
Compound class: Synthetic organic
Comment: Parent compound has PubChem CID 9947841.
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2D Structure
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SMILES / InChI / InChIKey
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Canonical SMILES CS(=O)(=O)O.O=C1Nc2c(C1=Cc1ccc[nH]1)cc(cc2)c1cccnc1
Isomeric SMILES CS(=O)(=O)O.O=C1Nc2c(/C/1=C/c1ccc[nH]1)cc(cc2)c1cccnc1
InChI InChI=1S/C18H13N3O.CH4O3S/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13;1-5(2,3)4/h1-11,20H,(H,21,22);1H3,(H,2,3,4)/b16-10-;
InChI Key ZUDPNBZMAJGYTE-HYMQDMCPSA-N

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
CDC like kinase 2 CLK2/CLK2 Hs Inhibitor Inhibition 0.3 1.0 1.0
mitogen-activated protein kinase kinase kinase kinase 4 nd/HGK(MAP4K4) Hs Inhibitor Inhibition 0.6
ribosomal protein S6 kinase A1 Rsk1/RSK1 Hs Inhibitor Inhibition 0.9 10.0 2.0
cyclin dependent kinase 5 CDK5-p25/CDK5-p25 Hs Inhibitor Inhibition 1.5 1.0 0.0
fms related receptor tyrosine kinase 3 Flt3/FLT3 Hs Inhibitor Inhibition 1.6 0.0 1.0
microtubule affinity regulating kinase 4 nd/MARK4 Hs Inhibitor Inhibition 1.6
misshapen like kinase 1 MINK/MINK(MINK1) Hs Inhibitor Inhibition 1.7 6.0 1.0
protein kinase D3 nd/PKCnu(PRKD3) Hs Inhibitor Inhibition 1.9
protein kinase D1 PKCμ/PKCmu(PRKD1) Hs Inhibitor Inhibition 2.1 6.0 1.0
cyclin dependent kinase 2 CDK2-cyclin A/CDK2-cyclin A Hs Inhibitor Inhibition 2.1 1.0 0.0
Displaying the top 10 targets  View all targets in screen »