[<sup>3</sup>H]NPY (human, mouse, rat) | Ligand page | IUPHAR/BPS Guide to PHARMACOLOGY

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Ligands
[³H]NPY (human, mouse, rat)

[³H]NPY (human, mouse, rat)

GtoPdb Ligand ID: 1521

Synonyms: [³H]neuropeptide Y

Compound class: Peptide or derivative

View interactive charts of activity data across species

2D Structure

SMILES / InChI / InChIKey

Canonical SMILES	NCCCCC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N)Cc1ccc(cc1)O)CCCN=C(N)N)CCC(=O)N)CCCN=C(N)N)C(O)C)C(CC)C)CC(C)C)CC(=O)N)C(CC)C)Cc1ccc(cc1)O)Cc1c[nH]cn1)CCCN=C(N)N)CC(C)C)C)CO)Cc1ccc(cc1)O)Cc1ccc(cc1)O)CCCN=C(N)N)C)CCSC)CC(=O)O)CCC(=O)O)C)C)CC(=O)O)CCC(=O)O)CC(=O)N)CC(=O)O)NC(=O)C(NC(=O)C1CCCN1C(=O)C(Cc1ccc(cc1)O)N)CO
Isomeric SMILES	CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O)[C@@H](C)O)[C@@H](C)CC
InChI	InChI=1S/C189H285N55O57S/c1-15-93(7)148(179(295)234-128(81-140(193)254)168(284)226-123(74-92(5)6)171(287)239-149(94(8)16-2)180(296)240-150(99(13)247)181(297)222-115(31-22-67-208-189(202)203)156(272)220-117(56-59-139(192)253)161(277)218-113(29-20-65-206-187(198)199)157(273)224-121(151(195)267)76-101-38-48-107(249)49-39-101)238-172(288)126(79-104-44-54-110(252)55-45-104)229-167(283)127(80-105-86-204-90-210-105)230-159(275)114(30-21-66-207-188(200)201)219-164(280)122(73-91(3)4)225-154(270)96(10)212-173(289)133(88-245)236-166(282)125(78-103-42-52-109(251)53-43-103)228-165(281)124(77-102-40-50-108(250)51-41-102)227-158(274)112(28-19-64-205-186(196)197)216-152(268)95(9)211-155(271)119(62-72-302-14)221-169(285)130(84-146(263)264)232-162(278)118(58-61-144(259)260)217-153(269)97(11)213-176(292)136-33-24-68-241(136)182(298)98(12)214-163(279)129(83-145(261)262)231-160(276)116(57-60-143(257)258)215-142(256)87-209-175(291)135-32-23-70-243(135)185(301)132(82-141(194)255)235-170(286)131(85-147(265)266)233-177(293)138-35-26-71-244(138)184(300)120(27-17-18-63-190)223-174(290)134(89-246)237-178(294)137-34-25-69-242(137)183(299)111(191)75-100-36-46-106(248)47-37-100/h36-55,86,90-99,111-138,148-150,245-252H,15-35,56-85,87-89,190-191H2,1-14H3,(H2,192,253)(H2,193,254)(H2,194,255)(H2,195,267)(H,204,210)(H,209,291)(H,211,271)(H,212,289)(H,213,292)(H,214,279)(H,215,256)(H,216,268)(H,217,269)(H,218,277)(H,219,280)(H,220,272)(H,221,285)(H,222,297)(H,223,290)(H,224,273)(H,225,270)(H,226,284)(H,227,274)(H,228,281)(H,229,283)(H,230,275)(H,231,276)(H,232,278)(H,233,293)(H,234,295)(H,235,286)(H,236,282)(H,237,294)(H,238,288)(H,239,287)(H,240,296)(H,257,258)(H,259,260)(H,261,262)(H,263,264)(H,265,266)(H4,196,197,205)(H4,198,199,206)(H4,200,201,207)(H4,202,203,208)/t93-,94-,95-,96-,97-,98-,99+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,148-,149-,150-/m0/s1
InChI Key	XKWCTHKJQNUFOQ-HRPSIEBRSA-N

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Other Similar Sequences
neuropeptide Y {Sp: Human, Mouse, Rat}	Targets PrRP receptor; Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
NPY {Sp: Pig}	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
NPY-(13-36) (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
NPY-(2-36) (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
NPY-(3-36) (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
peptide YY {Sp: Human}	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
peptide YY {Sp: Mouse, Rat, Pig}	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
PYY-(13-36) (mouse, rat, pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
PYY-(3-36) {Sp: Human}	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
[¹²⁵I]NPY (human, mouse, rat)	Targets Y₁ receptor; Y₂ receptor
[¹²⁵I]PYY (pig)	Targets Y₁ receptor; Y₄ receptor
[Ala³¹,Aib³²]NPY (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
[Leu³¹,Pro³⁴]NPY (pig)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
[Leu³¹,Pro³⁴]PYY (pig)	Targets Y₁ receptor; Y₄ receptor
[Leu³¹,Pro³⁴]PYY (human)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
N-α-Ac-PYY-(22-36) (rat)	Targets Y₂ receptor
N-α-Ac-PYY-(25-36) (rat)	Targets Y₂ receptor
C2-NPY (pig)	Targets Y₂ receptor
NPY-(13-36) (human)	Targets Y₂ receptor
NPY-(16-36) (pig)	Targets Y₂ receptor
NPY-(20-36) (pig)	Targets Y₂ receptor
NPY-(22-36) (pig)	Targets Y₂ receptor
NPY-(26-36) (pig)	Targets Y₂ receptor
PYY-(3-36) (pig)	Targets Y₂ receptor
[D-Trp³²]NPY	Targets Y₂ receptor; Y₅ receptor
[Leu³¹,Pro³⁴]NPY	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
[Pro³⁴]PYY (human)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor
NPY-(2-36)	Targets Y₁ receptor; Y₂ receptor; Y₄ receptor; Y₅ receptor
PYY-(3-36) {Sp: Mouse, Rat}	Targets Y₄ receptor; Y₅ receptor
NPY-(18-36) (human, pig)	Targets PrRP receptor; Y₅ receptor
[Ala³¹,Aib³²]NPY	Targets Y₅ receptor
neuropeptide Y-(3-36) {Sp: Human, Mouse, Rat}	Targets Y₂ receptor
[¹²⁵I][Leu³¹,Pro³⁴]NPY	Targets Y₁ receptor
[¹²⁵I]PYY-(3-36) (human)	Targets Y₂ receptor
[Pro³⁴]NPY	Targets Y₁ receptor
NPY-(13-36)