glimepiride   Click here for help

GtoPdb Ligand ID: 6820

Synonyms: Amaryl® | glimepride | HOE-490 | Sugral®
Approved drug
glimepiride is an approved drug (FDA (1995))
Compound class: Synthetic organic
Comment: Only approved by the EMA (2007) to be used in combination with pioglitazone (Tandemact®). Note that the PubChem CID listed above refers to the non-isomeric molecule. We show the isomeric form which corresponds to the structure held with the INN record for this compound.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 9
Hydrogen bond donors 3
Rotatable bonds 11
Topological polar surface area 133.06
Molecular weight 490.22
XLogP 3.79
No. Lipinski's rules broken 0
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Canonical SMILES CCC1=C(C)CN(C1=O)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCC(CC1)C
Isomeric SMILES CCC1=C(C)CN(C1=O)C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)N[C@@H]1CC[C@H](CC1)C
InChI InChI=1S/C24H34N4O5S/c1-4-21-17(3)15-28(22(21)29)24(31)25-14-13-18-7-11-20(12-8-18)34(32,33)27-23(30)26-19-9-5-16(2)6-10-19/h7-8,11-12,16,19H,4-6,9-10,13-15H2,1-3H3,(H,25,31)(H2,26,27,30)/t16-,19-
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1995))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
5718 glimepiride
Synonyms Click here for help
Amaryl® | glimepride | HOE-490 | Sugral®
Database Links Click here for help
CAS Registry No. 93479-97-1
ChEMBL Ligand CHEMBL1481
DrugBank Ligand DB00222
DrugCentral Ligand 1300
GtoPdb PubChem SID 178103426
PubChem CID 3476
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UniChem Compound Search for chemical match using the InChIKey WIGIZIANZCJQQY-RUCARUNLSA-N
UniChem Connectivity Search for chemical match using the InChIKey WIGIZIANZCJQQY-RUCARUNLSA-N
Wikipedia Glimepiride

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Glimepiride (links to external site)
Cat. No. 2396