navarixin   Click here for help

GtoPdb Ligand ID: 8497

Synonyms: MK-7123 | MK7123 | SCH-527123 | SCH527123
Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Navarixin (SCH-527123, MK-7123) is a potent and orally bioavailable CXCR2/CXCR1 receptor antagonist [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 3
Rotatable bonds 8
Topological polar surface area 111.88
Molecular weight 397.16
XLogP 3.39
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CCC(c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C
Isomeric SMILES CC[C@H](c1ccc(o1)C)NC1=C(C(=O)C1=O)Nc1cccc(c1O)C(=O)N(C)C
InChI InChI=1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1
InChI Key RXIUEIPPLAFSDF-CYBMUJFWSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxo-1-cyclobutenyl]amino]benzamide
International Nonproprietary Names Click here for help
INN number INN
9464 navarixin
Synonyms Click here for help
MK-7123 | MK7123 | SCH-527123 | SCH527123
Database Links Click here for help
Specialist databases
GPCRdb Ligand navarixin
Other databases
CAS Registry No. 473727-83-2
ChEMBL Ligand CHEMBL216981
GtoPdb PubChem SID 252166705
PubChem CID 9865554
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UniChem Compound Search for chemical match using the InChIKey RXIUEIPPLAFSDF-CYBMUJFWSA-N
UniChem Connectivity Search for chemical match using the InChIKey RXIUEIPPLAFSDF-CYBMUJFWSA-N