artenimol   Click here for help

GtoPdb Ligand ID: 9957

Synonyms: DHA | dihydroartemisinin | GNF-Pf-5634
Approved drug Antimalarial Ligand
artenimol is an approved drug (EMA (2011) in combination with piperaquine)
Compound class: Natural product
Comment: Artenimol is the active metabolite of artemisinin and all artemisinin-derived antimalarial compounds.
We show one representation of artenimol here. As with other natural products, there are alternative chemical structures due to the complex stereochemistry.

The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 57.15
Molecular weight 284.16
XLogP 2.81
No. Lipinski's rules broken 0
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Isomeric SMILES O[C@H]1O[C@@H]2O[C@@]3(C)CC[C@@H]4[C@]2([C@H]([C@H]1C)CC[C@H]4C)OO3
InChI InChI=1S/C15H24O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-13,16H,4-7H2,1-3H3/t8-,9-,10+,11+,12+,13-,14-,15-/m1/s1
Classification Click here for help
Compound class Natural product
Ligand families/groups Antimalarial ligands
Approved drug? Yes (EMA (2011) in combination with piperaquine)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
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IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
7777 artenimol
Synonyms Click here for help
DHA | dihydroartemisinin | GNF-Pf-5634
Database Links Click here for help
CAS Registry No. 71939-50-9 (source: Scifider)
DrugCentral Ligand 4194
GtoPdb PubChem SID 374883844
PubChem CID 3000518
Search Google for chemical match using the InChIKey BJDCWCLMFKKGEE-ISOSDAIHSA-N
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UniChem Compound Search for chemical match using the InChIKey BJDCWCLMFKKGEE-ISOSDAIHSA-N
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