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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 500 | 8q23.2 | KCNV1 | potassium voltage-gated channel modifier subfamily V member 1 | 2 |
| Mouse | 6 | 1 | 503 | 15 B3.3 | Kcnv1 | potassium channel, subfamily V, member 1 | |
| Rat | 6 | 1 | 503 | 7q31 | Kcnv1 | potassium voltage-gated channel modifier subfamily V member 1 | |
| Previous and Unofficial Names |
| HNKA | kv2.3 | kv2.3r | neuronal potassium channel alpha subunit | voltage-gated potassium channel subunit Kv2.3r | vibe | potassium channel, voltage gated modifier subfamily V, member 1 | potassium channel, voltage-gated modifier subfamily V, member 1 | potassium channel |
| Database Links |
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| Alphafold | Q6PIU1 (Hs), Q8BZN2 (Mm), P97557 (Rn) |
| ChEMBL Target | CHEMBL4524039 (Rn) |
| Ensembl Gene | ENSG00000164794 (Hs), ENSMUSG00000022342 (Mm), ENSRNOG00000004117 (Rn) |
| Entrez Gene | 27012 (Hs), 67498 (Mm), 60326 (Rn) |
| Human Protein Atlas | ENSG00000164794 (Hs) |
| KEGG Gene | hsa:27012 (Hs), mmu:67498 (Mm), rno:60326 (Rn) |
| OMIM | 608164 (Hs) |
| Pharos | Q6PIU1 (Hs) |
| RefSeq Nucleotide | NM_014379 (Hs), NM_026200 (Mm), NM_021697 (Rn) |
| RefSeq Protein | NP_055194 (Hs), NP_080476 (Mm), NP_067729 (Rn) |
| UniProtKB | Q6PIU1 (Hs), Q8BZN2 (Mm), P97557 (Rn) |
| Wikipedia | KCNV1 (Hs) |
| Associated Proteins |
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| Ion Selectivity and Conductance Comments |
| Kv8.1 is not functional on its own but modulates the properties of coexpressed Kv2.1. |
| Activator Comments | ||
| Kv8.1 has no function on its own, but it has important modulatory actions on Kv2 channels. |
| Tissue Distribution
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| Functional Assays
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| Physiological Functions
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| Phenotypes, Alleles and Disease Models
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Mouse data from MGI | ||||||||||||||||||||||||
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| Clinically-Relevant Mutations and Pathophysiology
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| Biologically Significant Variant Comments |
| A total of 173 SNPs have been identified in human KCNV1. For more information please see the entry on GeneCards. |
| General Comments |
| Despite sequence identity with other K+channel genes, KCNV1 does not display K+ channel activity when expressed in Xenopus laevis oocytes, instead inhibiting activity of Kv2 and Kv3 channels. |
1. Castellano A, Chiara MD, Mellström B, Molina A, Monje F, Naranjo JR, López-Barneo J. (1997) Identification and functional characterization of a K+ channel alpha-subunit with regulatory properties specific to brain. J Neurosci, 17 (12): 4652-61. [PMID:9169526]
2. Ebihara M, Ohba H, Kikuchi M, Yoshikawa T. (2004) Structural characterization and promoter analysis of human potassium channel Kv8.1 (KCNV1) gene. Gene, 325: 89-96. [PMID:14697513]
3. Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattéi MG, Lazdunski M. (1996) Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J, 15 (13): 3322-31. [PMID:8670833]
4. Mikami M, Yasuda T, Terao A, Nakamura M, Ueno S, Tanabe H, Tanaka T, Onuma T, Goto Y, Kaneko S, Sano A. (1999) Localization of a gene for benign adult familial myoclonic epilepsy to chromosome 8q23.3-q24.1. Am J Hum Genet, 65 (3): 745-51. [PMID:10441581]
5. Mori S, Nakamura M, Yasuda T, Ueno S, Kaneko S, Sano A. (2011) Remapping and mutation analysis of benign adult familial myoclonic epilepsy in a Japanese pedigree. J Hum Genet, 56 (10): 742-7. [PMID:21850007]
6. Salinas M, de Weille J, Guillemare E, Lazdunski M, Hugnot JP. (1997) Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. J Biol Chem, 272 (13): 8774-80. [PMID:9079713]
