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Gene and Protein Information  |
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| Species | TM | P Loops | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
| Human | 6 | 1 | 911 | 8q21.11 | KCNB2 | potassium voltage-gated channel subfamily B member 2 | 19 |
| Mouse | 6 | 1 | 907 | 1 4.5 cM | Kcnb2 | potassium voltage gated channel, Shab-related subfamily, member 2 | |
| Rat | 6 | 1 | 907 | 5q11 | Kcnb2 | potassium voltage-gated channel subfamily B member 2 | |
| Previous and Unofficial Names |
| CDRK | potassium voltage-gated channel subfamily B member 2 | potassium voltage-gated channel, Shab-related subfamily, member 2 | potassium channel, voltage gated Shab related subfamily B, member 2 | potassium channel, voltage gated Shab-related subfamily B, member 2 | potassium voltage gated channel |
| Database Links |
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| Alphafold | Q92953 (Hs), A6H8H5 (Mm), Q63099 (Rn) |
| ChEMBL Target | CHEMBL2321618 (Hs) |
| DrugBank Target | Q92953 (Hs) |
| Ensembl Gene | ENSG00000182674 (Hs), ENSMUSG00000092083 (Mm), ENSRNOG00000028991 (Rn) |
| Entrez Gene | 9312 (Hs), 98741 (Mm), 117105 (Rn) |
| Human Protein Atlas | ENSG00000182674 (Hs) |
| KEGG Gene | hsa:9312 (Hs), mmu:98741 (Mm), rno:117105 (Rn) |
| OMIM | 607738 (Hs) |
| Pharos | Q92953 (Hs) |
| RefSeq Nucleotide | NM_004770 (Hs), NM_001098528 (Mm), NM_054000 (Rn) |
| RefSeq Protein | NP_004761 (Hs), NP_001091998 (Mm), NP_446452 (Rn) |
| UniProtKB | Q92953 (Hs), A6H8H5 (Mm), Q63099 (Rn) |
| Wikipedia | KCNB2 (Hs) |
| Associated Proteins |
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| Ion Selectivity and Conductance |
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| Voltage Dependence |
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| Associated subunits (Human) |
| Kv5.1, Kv6.1-6.4, Kv8.1-8.2 and Kv9.1-9.3 |
Download all structure-activity data for this target as a CSV file 
| Gating inhibitors
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| Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Channel Blockers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Key to terms and symbols | View all chemical structures | Click column headers to sort | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Channel Blocker Comments | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Phencyclidine (PCP) also inhbits human Kv2.2 from human colonic circular smooth muscle (pIC50 roughly 4.3) [6] | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Tissue Distribution
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| Tissue Distribution Comments | ||||||||
| Also: Rabbit myocytes from corpus cavernosum (RT-PCR, [16]), Ferret cardiac myocytes (In situ hybridisation, [3]). | ||||||||
| Functional Assays
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| Physiological Functions
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| Physiological Functions Comments | ||||||||
| Species ([2]): Xenopus laevis embryonic spinal neurons | ||||||||
| Gene Expression and Pathophysiology
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| Biologically Significant Variant Comments |
| A total of 7585 SNPs have been identified in human KCNB2. For more information, please see the entry on GeneCards. |
| General Comments |
| The angiotensin II type 1 receptor mediates inhibition of Kv2.2 in the brainstem and hypothalamic neurons. It is a member of the mammalian Shab-related family. Some immunohistochemical studies performed with antibodies that were generated against an incorrect sequence of rat Kv2.2 [10], some studies on recombinant Kv2.2 channels using the rat cDNA may be confounded by incorrect sequence, as published in [11]. See [13] for correction. |
1. Blaine JT, Ribera AB. (1998) Heteromultimeric potassium channels formed by members of the Kv2 subfamily. J Neurosci, 18 (23): 9585-93. [PMID:9822719]
2. Blaine JT, Taylor AD, Ribera AB. (2004) Carboxyl tail region of the Kv2.2 subunit mediates novel developmental regulation of channel density. J Neurophysiol, 92 (6): 3446-54. [PMID:15306626]
3. Brahmajothi MV, Morales MJ, Liu S, Rasmusson RL, Campbell DL, Strauss HC. (1996) In situ hybridization reveals extensive diversity of K+ channel mRNA in isolated ferret cardiac myocytes. Circ Res, 78 (6): 1083-9. [PMID:8635239]
4. Escoubas P, Diochot S, Célérier ML, Nakajima T, Lazdunski M. (2002) Novel tarantula toxins for subtypes of voltage-dependent potassium channels in the Kv2 and Kv4 subfamilies. Mol Pharmacol, 62 (1): 48-57. [PMID:12065754]
5. Fink M, Duprat F, Lesage F, Heurteaux C, Romey G, Barhanin J, Lazdunski M. (1996) A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. J Biol Chem, 271 (42): 26341-8. [PMID:8824288]
6. Frey BW, Lynch FT, Kinsella JM, Horowitz B, Sanders KM, Carl A. (2000) Blocking of cloned and native delayed rectifier K channels from visceral smooth muscles by phencyclidine. Neurogastroenterol Motil, 12 (6): 509-16. [PMID:11123705]
7. Hermanstyne TO, Kihira Y, Misono K, Deitchler A, Yanagawa Y, Misonou H. (2010) Immunolocalization of the voltage-gated potassium channel Kv2.2 in GABAergic neurons in the basal forebrain of rats and mice. J Comp Neurol, 518 (21): 4298-310. [PMID:20853508]
8. Herrington J, Solly K, Ratliff KS, Li N, Zhou YP, Howard A, Kiss L, Garcia ML, McManus OB, Deng Q et al.. (2011) Identification of novel and selective Kv2 channel inhibitors. Mol Pharmacol, 80 (6): 959-64. [PMID:21948463]
9. Herrington J, Zhou YP, Bugianesi RM, Dulski PM, Feng Y, Warren VA, Smith MM, Kohler MG, Garsky VM, Sanchez M et al.. (2006) Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion. Diabetes, 55 (4): 1034-42. [PMID:16567526]
10. Hwang PM, Fotuhi M, Bredt DS, Cunningham AM, Snyder SH. (1993) Contrasting immunohistochemical localizations in rat brain of two novel K+ channels of the Shab subfamily. J Neurosci, 13 (4): 1569-76. [PMID:8463836]
11. Hwang PM, Glatt CE, Bredt DS, Yellen G, Snyder SH. (1992) A novel K+ channel with unique localizations in mammalian brain: molecular cloning and characterization. Neuron, 8 (3): 473-81. [PMID:1550672]
12. Johnston J, Griffin SJ, Baker C, Skrzypiec A, Chernova T, Forsythe ID. (2008) Initial segment Kv2.2 channels mediate a slow delayed rectifier and maintain high frequency action potential firing in medial nucleus of the trapezoid body neurons. J Physiol (Lond.), 586 (14): 3493-509. [PMID:18511484]
13. Kihira Y, Hermanstyne TO, Misonou H. (2010) Formation of heteromeric Kv2 channels in mammalian brain neurons. J Biol Chem, 285 (20): 15048-55. [PMID:20202934]
14. Lan M, Shi Y, Han Z, Hao Z, Pan Y, Liu N, Guo C, Hong L, Wang J, Qiao T et al.. (2005) Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells. Cancer Biol Ther, 4 (12): 1342-7. [PMID:16258262]
15. Malin SA, Nerbonne JM. (2002) Delayed rectifier K+ currents, IK, are encoded by Kv2 alpha-subunits and regulate tonic firing in mammalian sympathetic neurons. J Neurosci, 22 (23): 10094-105. [PMID:12451110]
16. Malysz J, Farrugia G, Ou Y, Szurszewski JH, Nehra A, Gibbons SJ. (2002) The Kv2.2 alpha subunit contributes to delayed rectifier K(+) currents in myocytes from rabbit corpus cavernosum. J Androl, 23 (6): 899-910. [PMID:12399537]
17. Salinas M, de Weille J, Guillemare E, Lazdunski M, Hugnot JP. (1997) Modes of regulation of shab K+ channel activity by the Kv8.1 subunit. J Biol Chem, 272 (13): 8774-80. [PMID:9079713]
18. Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M. (1997) New modulatory alpha subunits for mammalian Shab K+ channels. J Biol Chem, 272 (39): 24371-9. [PMID:9305895]
19. Schmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, Kenyon JL, Horowitz B. (1998) Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles. Am J Physiol, 274 (5 Pt 1): G901-11. [PMID:9612272]
20. Tsantoulas C, Zhu L, Yip P, Grist J, Michael GJ, McMahon SB. (2014) Kv2 dysfunction after peripheral axotomy enhances sensory neuron responsiveness to sustained input. Exp Neurol, 251: 115-26. [PMID:24252178]
21. Wible BA, Yang Q, Kuryshev YA, Accili EA, Brown AM. (1998) Cloning and expression of a novel K+ channel regulatory protein, KChAP. J Biol Chem, 273 (19): 11745-51. [PMID:9565597]
22. Xu C, Lu Y, Tang G, Wang R. (1999) Expression of voltage-dependent K(+) channel genes in mesenteric artery smooth muscle cells. Am J Physiol, 277 (5): G1055-63. [PMID:10564112]
23. Yan L, Figueroa DJ, Austin CP, Liu Y, Bugianesi RM, Slaughter RS, Kaczorowski GJ, Kohler MG. (2004) Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes, 53 (3): 597-607. [PMID:14988243]
