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Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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3',5'-Cyclic nucleotide phosphodiesterases (PDEs, 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3',5'-cyclic nucleotide (usually cyclic AMP or cyclic GMP). Isobutylmethylxanthine is a nonselective inhibitor with an IC50 value in the millimolar range for all isoforms except PDE 8A, 8B and 9A. A 2',3'-cyclic nucleotide 3'-phosphodiesterase (E.C. 3.1.4.37 CNPase) activity is associated with myelin formation in the development of the CNS.

Enzymes

1299
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PDE1A (phosphodiesterase 1A) C Show summary »

PDE1B (phosphodiesterase 1B) C Show summary »

PDE1C (phosphodiesterase 1C) C Show summary »

PDE2A (phosphodiesterase 2A) C Show summary »

PDE3A (phosphodiesterase 3A) C Show summary » More detailed page go icon to follow link

PDE3B (phosphodiesterase 3B) C Show summary »


Target Id 1299
Nomenclature phosphodiesterase 3B
Common abbreviation PDE3B
Previous and unofficial names cGMP-inhibited cAMP-PDE | phosphodiesterase 3B cGMP-inhibited | phosphodiesterase 3B, cGMP-inhibited
Genes PDE3B (Hs), Pde3b (Mm), Pde3b (Rn)
Ensembl ID ENSG00000152270 (Hs), ENSMUSG00000030671 (Mm), ENSRNOG00000011417 (Rn)
UniProtKB AC Q13370 (Hs), Q61409 (Mm), Q63085 (Rn)
EC number
3.1.4.17
Endogenous inhibitors
cyclic GMP (Selective)
Selective inhibitors
cilostamide pIC50 7.3 [42]
cilostazol pIC50 6.4 [42]
milrinone pIC50 6.0 [42]
inamrinone pIC50 4.5 [42]

PDE4A (phosphodiesterase 4A) C Show summary » More detailed page go icon to follow link

PDE4B (phosphodiesterase 4B) C Show summary » More detailed page go icon to follow link

PDE4C (phosphodiesterase 4C) C Show summary » More detailed page go icon to follow link

PDE4D (phosphodiesterase 4D) C Show summary » More detailed page go icon to follow link

PDE5A (phosphodiesterase 5A) C Show summary » More detailed page go icon to follow link

PDE6A (phosphodiesterase 6A) C Show summary »

PDE6B (phosphodiesterase 6B) C Show summary » More detailed page go icon to follow link

PDE6C (phosphodiesterase 6C) C Show summary »

PDE6D (phosphodiesterase 6D) C Show summary »

PDE6G (phosphodiesterase 6G) C Show summary »

PDE6H (phosphodiesterase 6H) C Show summary »

PDE7A (phosphodiesterase 7A) C Show summary »

PDE7B (phosphodiesterase 7B) C Show summary » More detailed page go icon to follow link

PDE8A (phosphodiesterase 8A) C Show summary » More detailed page go icon to follow link

PDE8B (phosphodiesterase 8B) C Show summary »

PDE9A (phosphodiesterase 9A) C Show summary »

PDE10A (phosphodiesterase 10A) C Show summary » More detailed page go icon to follow link

PDE11A (phosphodiesterase 11A) C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SP, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL et al. (2021) THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes. Br J Pharmacol. 178 Suppl 1:S313-S411.