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Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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3',5'-Cyclic nucleotide phosphodiesterases (PDEs, 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3',5'-cyclic nucleotide (usually cyclic AMP or cyclic GMP). Isobutylmethylxanthine is a nonselective inhibitor with an IC50 value in the millimolar range for all isoforms except PDE 8A, 8B and 9A. A 2',3'-cyclic nucleotide 3'-phosphodiesterase (E.C. 3.1.4.37 CNPase) activity is associated with myelin formation in the development of the CNS.

Enzymes

1309
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PDE1A (phosphodiesterase 1A) C Show summary »

PDE1B (phosphodiesterase 1B) C Show summary »

PDE1C (phosphodiesterase 1C) C Show summary »

PDE2A (phosphodiesterase 2A) C Show summary »

PDE3A (phosphodiesterase 3A) C Show summary » More detailed page go icon to follow link

PDE3B (phosphodiesterase 3B) C Show summary »

PDE4A (phosphodiesterase 4A) C Show summary » More detailed page go icon to follow link

PDE4B (phosphodiesterase 4B) C Show summary » More detailed page go icon to follow link

PDE4C (phosphodiesterase 4C) C Show summary » More detailed page go icon to follow link

PDE4D (phosphodiesterase 4D) C Show summary » More detailed page go icon to follow link

PDE5A (phosphodiesterase 5A) C Show summary » More detailed page go icon to follow link

PDE6A (phosphodiesterase 6A) C Show summary »

PDE6B (phosphodiesterase 6B) C Show summary » More detailed page go icon to follow link

PDE6C (phosphodiesterase 6C) C Show summary »

PDE6D (phosphodiesterase 6D) C Show summary »

PDE6G (phosphodiesterase 6G) C Show summary »

PDE6H (phosphodiesterase 6H) C Show summary »

PDE7A (phosphodiesterase 7A) C Show summary »

PDE7B (phosphodiesterase 7B) C Show summary » More detailed page go icon to follow link

PDE8A (phosphodiesterase 8A) C Show summary » More detailed page go icon to follow link

PDE8B (phosphodiesterase 8B) C Show summary »

PDE9A (phosphodiesterase 9A) C Show summary »


Target Id 1309
Nomenclature phosphodiesterase 9A
Common abbreviation PDE9A
Previous and unofficial names high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | PDE9A1
Genes PDE9A (Hs), Pde9a (Mm), Pde9a (Rn)
Ensembl ID ENSG00000160191 (Hs), ENSMUSG00000041119 (Mm), ENSRNOG00000001174 (Rn)
UniProtKB AC O76083 (Hs), O70628 (Mm)
EC number
3.1.4.17
Rank order of affinity cyclic GMP >> cyclic AMP  [12]
Inhibitors
SCH51866 pIC50 5.8 [12]
zaprinast pIC50 4.5 [12]

PDE10A (phosphodiesterase 10A) C Show summary » More detailed page go icon to follow link

PDE11A (phosphodiesterase 11A) C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.