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Phosphodiesterases, 3',5'-cyclic nucleotide (PDEs) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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3',5'-Cyclic nucleotide phosphodiesterases (PDEs, 3',5'-cyclic-nucleotide 5'-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3',5'-cyclic nucleotide (usually cyclic AMP or cyclic GMP). Isobutylmethylxanthine is a nonselective inhibitor with an IC50 value in the millimolar range for all isoforms except PDE 8A, 8B and 9A. A 2',3'-cyclic nucleotide 3'-phosphodiesterase (E.C. 3.1.4.37 CNPase) activity is associated with myelin formation in the development of the CNS.

Enzymes

1314
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PDE1A (phosphodiesterase 1A) C Show summary »

PDE1B (phosphodiesterase 1B) C Show summary »

PDE1C (phosphodiesterase 1C) C Show summary »

PDE2A (phosphodiesterase 2A) C Show summary »

PDE3A (phosphodiesterase 3A) C Show summary » More detailed page go icon to follow link

PDE3B (phosphodiesterase 3B) C Show summary »

PDE4A (phosphodiesterase 4A) C Show summary » More detailed page go icon to follow link

PDE4B (phosphodiesterase 4B) C Show summary » More detailed page go icon to follow link

PDE4C (phosphodiesterase 4C) C Show summary » More detailed page go icon to follow link

PDE4D (phosphodiesterase 4D) C Show summary » More detailed page go icon to follow link

PDE5A (phosphodiesterase 5A) C Show summary » More detailed page go icon to follow link

PDE6A (phosphodiesterase 6A) C Show summary »

PDE6B (phosphodiesterase 6B) C Show summary » More detailed page go icon to follow link

PDE6C (phosphodiesterase 6C) C Show summary »


Target Id 1314
Nomenclature phosphodiesterase 6C
Common abbreviation PDE6C
Previous and unofficial names cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' | phosphodiesterase 6C, cGMP specific, cone, alpha prime | phosphodiesterase 6C, cGMP-specific, cone, alpha prime
Genes PDE6C (Hs), Pde6c (Mm), Pde6c (Rn)
Ensembl ID ENSG00000095464 (Hs), ENSMUSG00000024992 (Mm), ENSRNOG00000016593 (Rn)
UniProtKB AC P51160 (Hs), Q91ZQ1 (Mm)
EC number
3.1.4.17
Inhibitors
sildenafil pIC50 7.4 [45]
PDE4 inhibitor 16 pIC50 5.5 [49]

PDE6D (phosphodiesterase 6D) C Show summary »

PDE6G (phosphodiesterase 6G) C Show summary »

PDE6H (phosphodiesterase 6H) C Show summary »

PDE7A (phosphodiesterase 7A) C Show summary »

PDE7B (phosphodiesterase 7B) C Show summary » More detailed page go icon to follow link

PDE8A (phosphodiesterase 8A) C Show summary » More detailed page go icon to follow link

PDE8B (phosphodiesterase 8B) C Show summary »

PDE9A (phosphodiesterase 9A) C Show summary »

PDE10A (phosphodiesterase 10A) C Show summary » More detailed page go icon to follow link

PDE11A (phosphodiesterase 11A) C Show summary »

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

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Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2019) The Concise Guide to PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol. 176 Issue S1: S297-S396.