Synonyms: Alphaquine® | Amdaquine® | Amoquin® | Camoquin® | Flavoquine®
amodiaquine is an approved drug
Compound class:
Synthetic organic
Comment: Amodiaquine is a 4-aminoquinoline antimalarial compound related to chloroquine.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY. Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Bioactivity Comments |
The interaction table below provides data from an evaluation of the antimalarial (asexual blood stage) activity of amodiaquine, using a panel of P. falciparum strains. Note that much of the bioactivity associated with amodiaquine relates to use of various hydrochloride salt and hydrate forms. Amodiaquine is reported to rescue SARS-CoV-2 infected Vero-E6 cells from death, with an EC50 of 5 μM in a plaque assay [4]. Amodiaquine is one of a number of drugs that are cationic amphiphilic in nature, for which anti-SARS-CoV-2 activity has been identified in drug repurposing screens. Tummino et al. (2021; bioRxiv preprint PMID: 33791693 target="_blank") suggest that this antiviral activity is most likely a result of the drug promoting phospholipidosis via disruption of lipid homeostasis. |
Whole organism assay data | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | Click on species/strain names for details | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
CYP2C8 | Converts arachidonic acid to 11(R)-12(S)-epoxyeicosatrienoic acid or 14(R)-15(S)-epoxyeicosatrienoic acid [5]. Drug substrates include amodiaquine and paclitaxel [1]. |