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Synonyms: Alphaquine® | Amdaquine® | Amoquin® | Camoquin® | Flavoquine®
amodiaquine is an approved drug
Compound class: Synthetic organic
Comment: Amodiaquine is a 4-aminoquinoline antimalarial compound related to chloroquine.
The Malaria tab on this ligand page provides additional curator comments of relevance to the Guide to MALARIA PHARMACOLOGY.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|No information available.|
|Summary of Clinical Use|
|Amodiaquine does not have FDA or EMA approval but is the active antimalarial compound contained in a number of drugs that are approved in jurisdictions in Africa (Kenya and Tanzania), Colombia and Pakistan. It is used to treat uncomplicated P. falciparum malaria, usually in combination with artesunate. Amodiaquine should not be used as a preventative therapy. Recommendations for the use of amodiaquine + artesunate are provided in the WHO Guidelines for the treatment of malaria .|