(R,S)-4-PPG   Click here for help

GtoPdb Ligand ID: 1406

Synonyms: (R,S)-4-phosphonophenylglycine | (RS)PPG
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 6
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 130.66
Molecular weight 231.03
XLogP -3.6
No. Lipinski's rules broken 0
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Canonical SMILES OC(=O)C(c1ccc(cc1)P(=O)(O)O)N
Isomeric SMILES OC(=O)C(c1ccc(cc1)P(=O)(O)O)N
InChI InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
mGlu8 receptor Hs Agonist Full agonist 6.7 pEC50 - 1-3
pEC50 6.7 [1-3]
mGlu4 receptor Hs Agonist Full agonist 5.3 pEC50 - 1-2
pEC50 5.3 [1-2]
mGlu6 receptor Hs Agonist Full agonist 5.3 pEC50 - 1,3
pEC50 5.3 [1,3]
mGlu7 receptor Hs Agonist Full agonist 3.7 pIC50 - 1-2
pIC50 3.7 [1-2]
Ligand mentioned in the following text fields