acipimox   Click here for help

GtoPdb Ligand ID: 1596

Synonyms: Olbetam®
Approved drug
acipimox is an approved drug (UK (2003))
Compound class: Synthetic organic
Comment: Acipimox is a nicotinic acid derivative.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 77.13
Molecular weight 154.04
XLogP -2.06
No. Lipinski's rules broken 0
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Canonical SMILES [O-][n+]1cc(ncc1C)C(=O)O
Isomeric SMILES [O-][n+]1cc(ncc1C)C(=O)O
InChI InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10)
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
HCA2 receptor Hs Agonist Full agonist 5.2 – 5.6 pEC50 - 1-2
pEC50 5.2 – 5.6 (EC50 6.31x10-6 – 2.51x10-6 M) [1-2]
Ligand mentioned in the following text fields