acipimox   Click here for help

GtoPdb Ligand ID: 1596

Synonyms: Olbetam®
Approved drug
acipimox is an approved drug (UK (2003))
Compound class: Synthetic organic
Comment: Acipimox is a nicotinic acid derivative.
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: acipimox

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 77.13
Molecular weight 154.04
XLogP -2.06
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES [O-][n+]1cc(ncc1C)C(=O)O
Isomeric SMILES [O-][n+]1cc(ncc1C)C(=O)O
InChI InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10)
No information available.
Summary of Clinical Use Click here for help
Used as an adjunct or alternative treatment in hyperlipidemias of types IIb and IV in patients who have not responded adequately to other lipid-regulating drugs such as a statin or fibrate, and lifestyle changes (including diet, exercise, and weight reduction). Not approved by the US FDA or the EMA, but is approved by national regulatory agencies.
External links Click here for help