bicuculline

Ligand id: 2312

Name: bicuculline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 1
Topological polar surface area 66.46
Molecular weight 367.11
XLogP 2.51
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
KCa2.1 Hs Channel blocker Antagonist 4.8 pIC50 - 1
pIC50 4.8 (IC50 1.6x10-5 M) [1]
Voltage: 80.0 mV
KCa2.2 Rn Channel blocker Antagonist 4.6 pIC50 - 1
pIC50 4.6 [1]
GABAA receptor α1 subunit Hs Antagonist Antagonist - - -
[Binds to: GABA site]
GABAA receptor α2 subunit Hs Antagonist Antagonist - - -
[Binds to: GABA site]
GABAA receptor α3 subunit Hs Antagonist Antagonist - - -
[Binds to: GABA site]
GABAA receptor α4 subunit Hs Antagonist Antagonist - - -
[Binds to: GABA site]
GABAA receptor α5 subunit Hs Antagonist Antagonist - - -
[Binds to: GABA site]
GABAA receptor α6 subunit Hs Antagonist Antagonist - - -
[Binds to: GABA site]
Targets where the ligand is described in the comment field
Target Comment
Ligand mentioned in the following text fields