himbacine

Ligand id: 324

Name: himbacine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 29.54
Molecular weight 345.27
XLogP 5.43
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
M2 receptor Hs Antagonist Antagonist 7.9 – 8.4 pKi - 2-5
pKi 7.9 – 8.4 [2-5]
M4 receptor Hs Antagonist Antagonist 7.9 – 8.4 pKi - 1-3,5
pKi 8.4 (Ki 4x10-9 M) [1]
pKi 7.9 – 8.2 [2-3,5]
M2 receptor Rn Antagonist Antagonist 7.9 pKi - 4
pKi 7.9 [4]
M3 receptor Hs Antagonist Antagonist 6.9 – 7.2 pKi - 2-3,5
pKi 6.9 – 7.2 [2-3,5]
M1 receptor Hs Antagonist Antagonist 6.7 – 7.1 pKi - 2-3,5
pKi 6.7 – 7.1 [2-3,5]
M5 receptor Hs Antagonist Antagonist 5.4 – 6.5 pKi - 2-3,5
pKi 5.4 – 6.5 [2-3,5]