Synonyms: Adrucil® | Carac®
5-fluorouracil is an approved drug (FDA (1962))
Compound class:
Synthetic organic
Comment: Fluoroacil is the active metabolite of the prodrugs capecitabine and floxuridine.
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Bioactivity Comments |
We have been unable to find publicly available bioactivity data for this drug at its proposed molecular target (thymidylate synthase) to substantiate its MMOA, and have therefore not tagged a primary drug target. |
Transporters Moving this Compound Across a Lipid Membrane | ||||||||
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Targets where the ligand is described in the comment field | |
Target | Comment |
dihydropyrimidine dehydrogenase | Dihydropyrimidine dehydrogenase is required for the first and rate-limiting step of pyrimidine catabolism. In addition to degrading pyrimidines, it also breaks down pyrimidine-based 5-fluorouracil, the anticancer cytostatic agent that is produced from chemotherapeutic prodrugs including capecitabine and tegafur. |