LK 204-545

Ligand id: 544

Name: LK 204-545

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 5
Rotatable bonds 17
Topological polar surface area 145.1
Molecular weight 484.23
XLogP 1.36
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
β1-adrenoceptor Hs Antagonist Antagonist 8.5 pKi - 1
pKi 8.5 [1]
β2-adrenoceptor Hs Antagonist Antagonist 5.2 pKi - 1
pKi 5.2 [1]