nadolol

Ligand id: 554

Name: nadolol

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Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 81.95
Molecular weight 309.19
XLogP 1.17
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
β2-adrenoceptor Hs Antagonist Antagonist 7.0 – 8.6 pKi - 1-2
pKi 7.0 – 8.6 [1-2]
β1-adrenoceptor Hs Antagonist Antagonist 6.9 pKi - 2
pKi 6.9 [2]
β3-adrenoceptor Hs Antagonist Antagonist 6.3 pKi - 2
pKi 6.3 [2]