KW-2449

Ligand id: 5691

Name: KW-2449

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 61.02
Molecular weight 332.16
XLogP 3.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
ABL proto-oncogene 1, non-receptor tyrosine kinase Hs Inhibitor Inhibition 7.8 pIC50 - 2
pIC50 7.8 (IC50 1.4x10-8 M) [2]
aurora kinase A Hs Inhibitor Inhibition 7.3 pIC50 - 2
pIC50 7.3 (IC50 4.8x10-8 M) [2]
aurora kinase B Hs Inhibitor Inhibition 7.3 pIC50 - 2
pIC50 7.3 (IC50 4.8x10-8 M) [2]
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
fms related tyrosine kinase 3 Hs Inhibitor Inhibition 7.8 pKd - 1
pKd 7.8 (Kd 1.5x10-8 M) [1]
fms related tyrosine kinase 3 Hs Inhibitor Inhibition 8.2 pIC50 - 2
pIC50 8.2 (IC50 6.6x10-9 M) [2]