KW-2449

Ligand id: 5691

Name: KW-2449

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 61.02
Molecular weight 332.16
XLogP 3.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value Parameter
serine/threonine kinase 17a DRAK1 Hs Inhibitor Inhibition 8.5 pKd
myosin light chain kinase 3 MLCK Hs Inhibitor Inhibition 8.4 pKd
serine/threonine kinase 17b DRAK2 Hs Inhibitor Inhibition 8.3 pKd
mitogen-activated protein kinase kinase kinase 19 YSK4 Hs Inhibitor Inhibition 8.3 pKd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(T315I)-phosphorylated Hs Inhibitor Inhibition 8.2 pKd
fms related tyrosine kinase 3 FLT3(K663Q) Hs Inhibitor Inhibition 8.2 pKd
BMP2 inducible kinase BIKE Hs Inhibitor Inhibition 8.0 pKd
mitogen-activated protein kinase kinase kinase kinase 2 MAP4K2 Hs Inhibitor Inhibition 8.0 pKd
ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1(T315I)-nonphosphorylated Hs Inhibitor Inhibition 7.9 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D,T670I) Hs Inhibitor Inhibition 7.9 pKd
Displaying the top 10 targets  View all targets in screen »