pazopanib   

GtoPdb Ligand ID: 5698

Synonyms: GW 786034 | indazolylpyrimidine 13 [4] | Votrient®
pazopanib is an approved drug (FDA (2009), EMA (2010))
Compound class: Synthetic organic
Comment: Pazopanib is a Type-1 kinase inhibitor. Its discovery is reported in [5]. It targets multiple receptor tyrosine kinases (VEGFR1, VEGFR2, VEGFR3, PDGFRβ, FGFR1, Kit and CSF1R).
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 127.41
Molecular weight 437.16
XLogP 3.34
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES CN(c1ccc2c(c1)nn(c2C)C)c1ccnc(n1)Nc1ccc(c(c1)S(=O)(=O)N)C
Isomeric SMILES CN(c1ccc2c(c1)nn(c2C)C)c1ccnc(n1)Nc1ccc(c(c1)S(=O)(=O)N)C
InChI InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChI Key CUIHSIWYWATEQL-UHFFFAOYSA-N
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 7.8 pKd - 2
pKd 7.8 (Kd 1.4x10-8 M) [2]
fms related receptor tyrosine kinase 1 Hs Inhibitor Inhibition 8.0 pIC50 - 4
pIC50 8.0 (IC50 1x10-8 M) [4]
kinase insert domain receptor Hs Inhibitor Inhibition 7.5 pIC50 - 4
pIC50 7.5 (IC50 3x10-8 M) [4]
fms related receptor tyrosine kinase 4 Hs Inhibitor Inhibition 7.3 pIC50 - 4
pIC50 7.3 (IC50 4.7x10-8 M) [4]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 7.1 pIC50 - 4
pIC50 7.1 (IC50 7.4x10-8 M) [4]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 7.1 pIC50 - 4
pIC50 7.1 (IC50 8.4x10-8 M) [4]
KIT proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 6.8 pIC50 - 4
pIC50 6.8 (IC50 1.4x10-7 M) [4]
colony stimulating factor 1 receptor Hs Inhibitor Inhibition 6.8 pIC50 - 4
pIC50 6.8 (IC50 1.46x10-7 M) [4]