SU-14813

Ligand id: 5712

Name: SU-14813

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 103.26
Molecular weight 442.2
XLogP -0.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
SU-14813 exhibits potent antiangiogenic and antitumour activity in vivo [3].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 8.6 pKd - 1
⤷ pKd 8.6 (Kd 2.3x10-9 M) [1]
fms related tyrosine kinase 1 Hs Inhibitor Inhibition 8.7 pIC50 - 3
⤷ pIC50 8.7 (IC50 2x10-9 M) [3]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 8.4 pIC50 - 3
⤷ pIC50 8.4 (IC50 4x10-9 M) [3]
KIT proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 7.8 pIC50 - 3
⤷ pIC50 7.8 (IC50 1.5x10-8 M) [3]
kinase insert domain receptor Hs Inhibitor Inhibition 7.3 pIC50 - 3
⤷ pIC50 7.3 (IC50 5x10-8 M) [3]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 5.5 pIC50 - 3
⤷ pIC50 5.5 (IC50 3.5x10-6 M) [3]