SU-14813

Ligand id: 5712

Name: SU-14813

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 103.26
Molecular weight 442.2
XLogP -0.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
SU-14813 exhibits potent antiangiogenic and antitumour activity in vivo [3].
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 8.6 pKd - 1
⤷ pKd 8.6 (Kd 2.3x10-9 M) [1]
fms related receptor tyrosine kinase 1 Hs Inhibitor Inhibition 8.7 pIC50 - 3
⤷ pIC50 8.7 (IC50 2x10-9 M) [3]
platelet derived growth factor receptor beta Hs Inhibitor Inhibition 8.4 pIC50 - 3
⤷ pIC50 8.4 (IC50 4x10-9 M) [3]
KIT proto-oncogene, receptor tyrosine kinase Hs Inhibitor Inhibition 7.8 pIC50 - 3
⤷ pIC50 7.8 (IC50 1.5x10-8 M) [3]
kinase insert domain receptor Hs Inhibitor Inhibition 7.3 pIC50 - 3
⤷ pIC50 7.3 (IC50 5x10-8 M) [3]
fibroblast growth factor receptor 1 Hs Inhibitor Inhibition 5.5 pIC50 - 3
⤷ pIC50 5.5 (IC50 3.5x10-6 M) [3]