SU-14813

Ligand id: 5712

Name: SU-14813

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 7
Topological polar surface area 103.26
Molecular weight 442.2
XLogP -0.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1,4

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Value Parameter
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D,V654A) Hs Inhibitor Inhibition 9.6 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT(L576P) Hs Inhibitor Inhibition 9.5 pKd
platelet derived growth factor receptor beta PDGFRB Hs Inhibitor Inhibition 9.5 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D) Hs Inhibitor Inhibition 9.3 pKd
fms related tyrosine kinase 3 FLT3 Hs Inhibitor Inhibition 9.3 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT(V559D,T670I) Hs Inhibitor Inhibition 9.3 pKd
KIT proto-oncogene, receptor tyrosine kinase KIT Hs Inhibitor Inhibition 9.2 pKd
fms related tyrosine kinase 3 FLT3(K663Q) Hs Inhibitor Inhibition 9.1 pKd
platelet derived growth factor receptor alpha PDGFRA Hs Inhibitor Inhibition 9.0 pKd
fms related tyrosine kinase 3 FLT3(ITD) Hs Inhibitor Inhibition 8.7 pKd
Displaying the top 10 targets  View all targets in screen »