Syk inhibitor III   Click here for help

GtoPdb Ligand ID: 6048

Synonyms: NSC 10120 | NSC 105303 | NSC 170724 | SBB007833
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 61.6
Molecular weight 193.04
XLogP 1.68
No. Lipinski's rules broken 0
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Canonical SMILES [O-][N+](=O)C=Cc1ccc2c(c1)OCO2
Isomeric SMILES [O-][N+](=O)/C=C/c1ccc2c(c1)OCO2
InChI InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3+
Bioactivity Comments
This compound inhibits tyrosine phosphorylation and aggregation of platelets [3-4] by inhibiting integrin activation and therefore platelet responses to thrombin.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
spleen associated tyrosine kinase Primary target of this compound Hs Inhibitor Inhibition 5.6 pIC50 - 3
pIC50 5.6 (IC50 2.8x10-6 M) [3]
SRC proto-oncogene, non-receptor tyrosine kinase Hs Inhibitor Inhibition 4.6 pIC50 - 3
pIC50 4.6 (IC50 2.73x10-5 M) [3]