Syk inhibitor III   Click here for help

GtoPdb Ligand ID: 6048

Synonyms: NSC 10120 | NSC 105303 | NSC 170724 | SBB007833
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 61.6
Molecular weight 193.04
XLogP 1.68
No. Lipinski's rules broken 0
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Canonical SMILES [O-][N+](=O)C=Cc1ccc2c(c1)OCO2
Isomeric SMILES [O-][N+](=O)/C=C/c1ccc2c(c1)OCO2
InChI InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3+
1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011)
Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.
Nat Biotechnol, 29 (11): 1039-45. [PMID:22037377]
2. Gao Y, Davies SP, Augustin M, Woodward A, Patel UA, Kovelman R, Harvey KJ. (2013)
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Biochem J, 451 (2): 313-28. [PMID:23398362]
3. Wang WY, Hsieh PW, Wu YC, Wu CC. (2007)
Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity.
Biochem Pharmacol, 74 (4): 601-11. [PMID:17601492]
4. Wang WY, Wu YC, Wu CC. (2006)
Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosine kinase inhibitor.
Mol Pharmacol, 70 (4): 1380-9. [PMID:16837624]