Syk inhibitor III   Click here for help

GtoPdb Ligand ID: 6048

Synonyms: NSC 10120 | NSC 105303 | NSC 170724 | SBB007833
Compound class: Synthetic organic
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 2
Topological polar surface area 61.6
Molecular weight 193.04
XLogP 1.68
No. Lipinski's rules broken 0
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Canonical SMILES [O-][N+](=O)C=Cc1ccc2c(c1)OCO2
Isomeric SMILES [O-][N+](=O)/C=C/c1ccc2c(c1)OCO2
InChI InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3+

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen Click here for help
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
cyclin dependent kinase 9 CDK9-cyclin T1/CDK9-cyclin T1 Hs Inhibitor Inhibition 61.3 112.0 100.0
unc-51 like kinase 3 ULK3/ULK3 Hs Inhibitor Inhibition 65.4 111.0 91.0
Protein kinase G (PKG) 1 PKG1α/PKG1a Hs Inhibitor Inhibition 72.6 107.0 106.0
p21 (RAC1) activated kinase 2 PAK2/PAK2 Hs Inhibitor Inhibition 73.2 111.0 100.0
mitogen-activated protein kinase kinase kinase 2 nd/MEKK2 Hs Inhibitor Inhibition 76.9
BMX non-receptor tyrosine kinase Bmx/BMX(ETK) Hs Inhibitor Inhibition 77.6 98.0 110.0
MER proto-oncogene, tyrosine kinase Mer/c-MER Hs Inhibitor Inhibition 77.6 106.0 108.0
tousled like kinase 2 TLK2/TLK2 Hs Inhibitor Inhibition 77.9 99.0 97.0
protein kinase C delta PKCδ/PKCd Hs Inhibitor Inhibition 78.8 99.0 95.0
fibroblast growth factor receptor 4 FGFR4/FGFR4 Hs Inhibitor Inhibition 80.9 135.0 104.0
Displaying the top 10 targets  View all targets in screen »