tivozanib

Ligand id: 6058

Name: tivozanib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 107.74
Molecular weight 454.1
XLogP 3.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Tivozanib inhibits all three VEGF receptor tyrosine kinase enzymes with equal potency [3]. The drug formulation contains tivozanib hydrochloride monohydrate (PubChem CID 11547978).
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
kinase insert domain receptor Hs Inhibitor Inhibition 9.8 pIC50 - 3
pIC50 9.8 (IC50 1.6x10-10 M) [3]
fms related tyrosine kinase 1 Hs Inhibitor Inhibition 9.7 pIC50 - 3
pIC50 9.7 (IC50 2.1x10-10 M) [3]
fms related tyrosine kinase 4 Hs Inhibitor Inhibition 9.6 pIC50 - 3
pIC50 9.6 (IC50 2.4x10-10 M) [3]