tivozanib

Ligand id: 6058

Name: tivozanib

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 107.74
Molecular weight 454.1
XLogP 3.53
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1-2

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
ABL proto-oncogene 1, non-receptor tyrosine kinase Abl/ABL1 Hs Inhibitor Inhibition -6.0 -7.0
EPH receptor A2 EphA2/EPHA2 Hs Inhibitor Inhibition -3.0 -3.0
LCK proto-oncogene, Src family tyrosine kinase Lck activated Hs Inhibitor Inhibition -2.0 1.0
ABL proto-oncogene 2, non-receptor tyrosine kinase Arg/ABL2(ARG) Hs Inhibitor Inhibition -2.0 -1.0
EPH receptor B2 EphB2/EPHB2 Hs Inhibitor Inhibition -2.0 -1.0
fms related tyrosine kinase 4 Flt4/FLT4 Hs Inhibitor Inhibition -1.0 -1.0
LYN proto-oncogene, Src family tyrosine kinase Lyn/LYN Hs Inhibitor Inhibition -1.0 2.0
fms related tyrosine kinase 1 Flt1/FLT1(VEGFR1) Hs Inhibitor Inhibition 0.0 -1.0
Raf-1 proto-oncogene, serine/threonine kinase c-RAF/RAF1 Hs Inhibitor Inhibition 0.0 1.0
colony stimulating factor 1 receptor Fms/FMS Hs Inhibitor Inhibition 0.0 0.0
Displaying the top 10 targets  View all targets in screen »