anakinra   Click here for help

GtoPdb Ligand ID: 6972

Synonyms: antril | Kineret®
Approved drug Immunopharmacology Ligand
anakinra is an approved drug (FDA (no history prior to 2001), EMA (2002))
Comment: This drug is a recombinant, nonglycosylated form of the endogenous IL-1 receptor antagonist peptide with an additional methionine at the amino terminus compared to the endogenous peptide.
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Selectivity at catalytic receptors
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Interleukin-1 receptor, type I Primary target of this compound Hs Inhibitor Inhibition 7.8 pKd - 1
pKd 7.8 (Kd 1.5x10-8 M) [1]