L-serine   Click here for help

GtoPdb Ligand ID: 726

Abbreviated name: L-Ser
PDB Ligand
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 2
Topological polar surface area 83.55
Molecular weight 105.04
XLogP -3.96
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES OCC(C(=O)O)N
Isomeric SMILES OC[C@@H](C(=O)O)N
InChI InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChI Key MTCFGRXMJLQNBG-REOHCLBHSA-N
Natural/Endogenous Targets
Target
GPRC6 receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
serine palmitoyltransferase long chain base subunit 2
serine palmitoyltransferase long chain base subunit 3
serine palmitoyltransferase long chain base subunit 1
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
B0AT1 2
sodium-coupled neutral amino acid transporter 2 5
Alanine/serine/cysteine transporter 1
Sodium-coupled neutral amino acid transporter 5 6
B0AT2 2
NTT4 9
sodium-coupled neutral amino acid transporter 1 1
sodium-coupled neutral amino acid transporter 4 4
ATB0,+ 7
Alanine/serine/cysteine transporter 2
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPRC6 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 3.2 pEC50 - 8
pEC50 3.2 [8]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields