glycine   Click here for help

GtoPdb Ligand ID: 727

PDB Ligand
Compound class: Metabolite
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 63.32
Molecular weight 75.03
XLogP -3.35
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES NCC(=O)O
Isomeric SMILES NCC(=O)O
InChI InChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChI Key DHMQDGOQFOQNFH-UHFFFAOYSA-N
Bioactivity Comments
Glycine has been described as a coagonist with L-glutamic acid of NMDA receptors [4].
Natural/Endogenous Targets
Target
GluN1
GluN2A
GluN2B
GluN2C
GluN2D
Glycine Receptor (All subtypes)
glycine receptor α1 subunit
glycine receptor α2 subunit
glycine receptor α3 subunit
glycine receptor α4 subunit (pseudogene in humans)
glycine receptor β subunit
GPRC6 receptor
Enzymes Catalysing Reactions with this Compound as a Substrate or Product
Enzyme EC number Reaction Reference
Dipeptidase 1
Dipeptidase 2
Transporters Moving this Compound Across a Lipid Membrane
Transporter EC number Reaction Reference
GlyT1
GlyT2
Vesicular inhibitory amino acid transporter
Proton-coupled Amino acid Transporter 1 9
Proton-coupled Amino acid Transporter 2
Alanine/serine/cysteine transporter 2
B0AT1 3
B0AT2 3
B0AT3 10
NTT4 12
sodium-coupled neutral amino acid transporter 1 1
sodium-coupled neutral amino acid transporter 2 6
sodium-coupled neutral amino acid transporter 4 5
Sodium-coupled neutral amino acid transporter 5 8
Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
GPRC6 receptor Ligand is endogenous in the given species Hs Agonist Full agonist 3.6 pEC50 - 11
pEC50 3.6 [11]
Selectivity at ion channels
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
Glycine Receptor (All subtypes) Ligand is endogenous in the given species Hs Agonist Agonist 4.3 – 4.6 pEC50 - 2,7
pEC50 4.3 – 4.6 [2,7]
GluN1 Ligand is endogenous in the given species Hs Agonist Agonist - - -
[Binds to: glycine site]
GluN2A Ligand is endogenous in the given species Hs Agonist Agonist - - -
[Binds to: glycine site] GluN2D > GluN2C > GluN2B > GluN2A
GluN2B Ligand is endogenous in the given species Hs Agonist Agonist - - -
[Binds to: glycine site] GluN2D > GluN2C > GluN2B > GluN2A
GluN2C Ligand is endogenous in the given species Hs Agonist Agonist - - -
[Binds to: glycine site] GluN2D > GluN2C > GluN2B > GluN2A
GluN2D Ligand is endogenous in the given species Hs Agonist Agonist - - -
[Binds to: glycine site] GluN2D > GluN2C > GluN2B > GluN2A
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference
Ligand mentioned in the following text fields