CCL2   

GtoPdb Ligand ID: 771

Comment: CCL2 (generally known as MCP-1) is a CC family chemokine. It acts via the G protein-coupled receptors CCR2 and CCR4.
Species: Human
Natural/Endogenous Targets
Target
CCR2
CCR3
CCR5
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CCR3 Hs Agonist Full agonist 7.2 – 7.8 pKi - 2
pKi 7.2 – 7.8 [2]
CCR5 Hs Agonist Full agonist 7.5 pKi - 6
pKi 7.5 [6]
CCR2 Hs Agonist Full agonist 9.3 – 10.2 pIC50 - 1,4-5,7,9
pIC50 9.3 – 10.2 [1,4-5,7,9]
Additional information and targets (data relate to human unless otherwise stated)
Description Data Reference