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Abbreviated name: RTV
Synonyms: A-84538 | ABBOTT-84538 | ABT 538 | ABT-538 | Norvir®
ritonavir is an approved drug (EMA & FDA (1996))
Compound class: Synthetic organic
Comment: Ritonavir is an orally bioavailable antiviral that is generally administered in combination with other anti-HIV or anti-HCV drugs.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
View more information in the IUPHAR Pharmacology Education Project: ritonavir
|Inhibition of CYP3A4 by ritonavir blocks this metabolizing enzyme form breaking down other antiviral protease inhibitors, and in so-doing enhances the activity of the other protease inhibitors it is administered with. This activity means that potentially dangerous pharmacokinetic interactions are likely if ritonavir is administered with other drugs that are inhibitors of CYP3A (and also of CYP2D6) e.g. alfuzosin, amiodarone, cisapride, ergot alkaloids, flecainide, lovastatin, oral midazolam, pimozide, propafenone, quinidine, sildenafil, simvastatin and triazolam. St. John's wort is a CYP3A inducer that can decrease substrate drug levels to sub-therapeutic concentrations.
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