AR-M1000390   Click here for help

GtoPdb Ligand ID: 9005

Synonyms: AR-M390 | ARM-390
Compound class: Synthetic organic
Comment: AR-M1000390 is a nonpeptidic δ receptor selective agonist [2].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 32.34
Molecular weight 348.22
XLogP 4.23
No. Lipinski's rules broken 0
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Canonical SMILES CCN(C(=O)c1ccc(cc1)C(=C1CCNCC1)c1ccccc1)CC
Isomeric SMILES CCN(C(=O)c1ccc(cc1)C(=C1CCNCC1)c1ccccc1)CC
InChI InChI=1S/C23H28N2O/c1-3-25(4-2)23(26)21-12-10-19(11-13-21)22(18-8-6-5-7-9-18)20-14-16-24-17-15-20/h5-13,24H,3-4,14-17H2,1-2H3
Bioactivity Comments
Additional binding affinity data for this compound is reported in patent WO2006124687 A1 [1].
Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
δ receptor Primary target of this compound Hs Agonist Agonist 7.0 pKi - 2
pKi 7.0 (Ki 1.06x10-7 M) [2]
δ receptor Primary target of this compound Hs Agonist Agonist 9.1 pIC50 - 1
pIC50 9.1 (IC50 8.9x10-10 M) [1]
μ receptor Hs Agonist Agonist 5.4 pIC50 - 1
pIC50 5.4 (IC50 3.8x10-6 M) [1]
κ receptor Hs Agonist Agonist 5.1 pIC50 - 1
pIC50 5.1 (IC50 7.47x10-6 M) [1]