diclofenac   

GtoPdb Ligand ID: 2714

Synonyms: Cataflam® | CGP-45840B | GP-45840 | Voltaren® | Voltarol®
diclofenac is an approved drug (FDA (1988))
Compound class: Synthetic organic
Comment: Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID)
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2D Structure
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Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 49.33
Molecular weight 295.02
XLogP 3.9
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Canonical SMILES OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Isomeric SMILES OC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
InChI InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)
InChI Key DCOPUUMXTXDBNB-UHFFFAOYSA-N
No information available.
Summary of Clinical Use
Diclofenac is used to treat pain or inflammation caused by osteoarthritis and rheumatoid arthritis, but is also used to treat other conditions which benefit from the analgesic and antipyretic properties of NSAIDs.
Mechanism Of Action and Pharmacodynamic Effects
In addition to inhibiting prostaglandin synthesis (via inhibition of COX-1 and COX-2; prostaglandins normally sensitize nociceptors), diclofenac appears to inhibit leukocyte migration at inflammarory sites.