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Ligand id: 2714
View more information in the IUPHAR Pharmacology Education Project: diclofenac
Molecular properties generated using the CDK
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
1. Adamson DJ, Frew D, Tatoud R, Wolf CR, Palmer CN. (2002)
Diclofenac antagonizes peroxisome proliferator-activated receptor-gamma signaling.
Mol. Pharmacol., 61 (1): 7-12. [PMID:11752200]
2. Blobaum AL, Marnett LJ. (2007)
Structural and functional basis of cyclooxygenase inhibition.
J. Med. Chem., 50 (7): 1425-41. [PMID:17341061]
3. Kojo H, Fukagawa M, Tajima K, Suzuki A, Fujimura T, Aramori I, Hayashi K, Nishimura S. (2003)
Evaluation of human peroxisome proliferator-activated receptor (PPAR) subtype selectivity of a variety of anti-inflammatory drugs based on a novel assay for PPAR delta(beta).
J. Pharmacol. Sci., 93 (3): 347-55. [PMID:14646253]
4. Suzuki H, Sasaki E, Nakagawa A, Muraki Y, Hatano N, Muraki K. (2016)
Diclofenac, a nonsteroidal anti-inflammatory drug, is an antagonist of human TRPM3 isoforms.
Pharmacol Res Perspect, 4 (3): e00232. [PMID:27433342]
5. Zou J, Jin D, Chen W, Wang J, Liu Q, Zhu X, Zhao W. (2005)
Selective cyclooxygenase-2 inhibitors from Calophyllum membranaceum.
J. Nat. Prod., 68 (10): 1514-8. [PMID:16252917]